Investigating tRNA Fragments Predicted to Bind SARS-CoV-2
- Funded by University of Minnesota
- Total publications:0 publications
Grant number: unknown
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Key facts
Disease
COVID-19start year
-99Known Financial Commitments (USD)
$0Funder
University of MinnesotaPrincipal Investigator
PhD. Lynne BemisResearch Location
United States of AmericaLead Research Institution
Medical School, University of MinnesotaResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Unspecified
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
The COVID-19 pandemic has generated a great need to understand the biological mechanisms required for the regulation of corona viruses. Noncoding RNAs have been implicated in many aspects of viral infection, although they are largely unstudied in the corona viruses. Noncoding RNAs from the host have been shown to increase during certain viral infections and may stabilize the viral genome. tRNA fragments (tRFs) are a type of noncoding RNA associated with some viral infections. Led by Lynne Bemis, PhD, professor of biomedical sciences, this study will assess if one or more tRFs binds and regulates SARS-CoV-2. "New exploration of the binding of tRFs to SARS-CoV-2 will lead to new understanding of the RNA regulatory mechanisms, ultimately leading to new therapeutic interventions targeting SARS-CoV-2," said Bemis.