Return to homepagePandemic Pact

"LUng MAcrophage involvement in Lethal COVID-19 pathogenesis: an immunopathology approach to Actionable Mechanisms - LUMACOVID"

Grant number: unknown

Grant search

Key facts

  • Disease

    COVID-19

  • Known Financial Commitments (USD)

    $236,138.76

  • Funder

    BBVA Foundation (Spain)

  • Principal Investigator

    Ignacio Melero

  • Research Location

    Spain

  • Lead Research Institution

    Clínica Universidad de Navarra

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

By observing tissue samples from different organs, obtained postmortem from a score of patients shortly after their death in the intensive care unit, the authors of this project observed an exacerbated presence of macrophages. Macrophages are a key cell type in the body, for their role in trapping and destroying pathogens and eliminating dead cells. They are also essential in regulating the inflammatory response, and researchers consider them the main culprits of respiratory failure in COVID-19. Using advanced microscopy and gene expression techniques, the researchers will try to identify in this unique collection of micro-autopsy samples the mechanisms that explain the high presence and activation of macrophages.