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CoronaMito: Consequences of SARS-CoV-2 infection on mitochondrial function.

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • start year

    -99

  • Known Financial Commitments (USD)

    $0

  • Funder

    ANR

  • Principal Investigator

    Olivier Schwartz

  • Research Location

    France

  • Lead Research Institution

    Institut Pasteur / Paris

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The CoronaMito project, coordinated by Olivier Schwartz (Institut Pasteur / Paris), will study the impact of SARS-CoV-2 infection on the morphological remodeling and activity of mitochondria. The team's preliminary experiments show that viral infection causes mitochondrial fragmentation and cell death. The project will focus on discovering the underlying molecular mechanisms and determining the functional consequences of mitochondrial remodeling on cellular homeostasis and metabolism, viral spread and innate immune responses. It should allow a better understanding of the interactions between SARS-CoV-2 and mitochondria.