Return to homepagePandemic Pact

COST: To determine whether the severity of SARS-CoV-2 infection with age is associated with telomeric dysfunction.

Grant number: unknown

Grant search

Key facts

  • Disease

    COVID-19

  • start year

    -99

  • Known Financial Commitments (USD)

    $0

  • Funder

    ANR

  • Principal Investigator

    Delphine Benarroch-Popivker

  • Research Location

    France

  • Lead Research Institution

    Université Nice Sophia Antipolis

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Adults (18 and older)Older adults (65 and older)

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The COST project, coordinated by Delphine Benarroch-Popivker (UMR7284 - Institute for Research on Cancer and Aging (IRCAN) - Université Nice Sophia Antipolis), aims to show that the greater vulnerability of certain patients to a serious infection by SARS-CoV -2 is associated with telomeric dysfunction and that dexamethasone treatment decreases patient mortality by strengthening the protection of telomeres, thus preventing senescence and aging of cells. This work could help identify high-risk patients, based on the status of their telomeres and blood cell senescence (PBMC), providing a rational basis for the use of telomeres as biomarkers for detection and detection. early diagnosis of severe forms of SARS-CoV-2 infection.