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CALPRO: Role of calprotectin in emergency hematopoiesis of severe forms of COVID-19.

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $0

  • Funder

    ANR

  • Principal Investigator

    Eric Solary

  • Research Location

    France

  • Lead Research Institution

    Institut Gustave Roussy / Villejuif

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The CALPRO project, coordinated by Eric Solary (UMR 1287 - Institut Gustave Roussy / Villejuif), aims to explore the pathophysiological mechanisms involved in the emergency hematopoiesis observed in patients with severe Covid-19, and to explore the characteristics and the differentiation capacities of hematopoietic stem and progenitor cells (HSCSPs) of patients with hematologic malignancies in response to calprotectin. The identification of the effects of calprotectin and of the receptors involved at the level of CSPH could suggest therapeutic approaches capable of controlling the toxic feedback loop between mature and immature cells of the hematopoietic system which takes place in the most severe forms of the Covid-19.