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COVERI: Immunopathological activation of the endogenous retroviral protein HERV-W by SARS-CoV-2 in COVID-19 patients.

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • start year

    -99

  • Known Financial Commitments (USD)

    $0

  • Funder

    ANR

  • Principal Investigator

    Hervé Perron

  • Research Location

    France

  • Lead Research Institution

    Geneuro Innovation (GNI) / Lyon

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The COVERI project, coordinated by Hervé Perron (Geneuro Innovation (GNI) / Lyon), proposes to study the mechanism of the induction of the endogenous retroviral protein HERV-W by SARS-CoV-2, by analyzing a large number of 'samples from multicenter cohorts of Covid-19 patients in Europe. He will focus on determining the type of cell responsible for HERV-W production and looking for the intracellular pathway linked to the activation of HERV-W induced by SARS-CoV-2. The project should provide a proof of concept for the role of HERV proteins, known for their strong pro-inflammatory effect, in the genesis of Covid-19 immunoinflammatory syndromes.