COVI-COMPLECT: Role of the complement lectin pathway in the pathogenesis of SARS-CoV-2 infection

The COVI-COMPLECT project, coordinated by Nicole Thielens (UMR 5075 - Institut de Biologie Structurale (IBS) - CEA / Grenoble) aims to understand the role of the complement lectin pathway, a major player in innate antiviral immune defense, in the pathophysiogenesis of SARS-CoV-2 infection. He proposes to decipher the molecular mechanisms of interactions of SARS-CoV-2 proteins with components of the complement lectin pathway and to assess their functional consequences, including viral neutralization and complement activation. A better understanding of the relative roles of specific complement components, particularly those involved in the activation of the lectin pathway, would be useful in identifying possible patients at risk and in guiding potential therapy targeting the complement.