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S-VLP: Vaccination with synthetic lipid particles coated with trimeric envelope glycoprotein S of SARS-CoV-2.

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    ANR

  • Principal Investigator

    Winfried Weissenhorn

  • Research Location

    France

  • Lead Research Institution

    Université Grenoble Alpes / Grenoble

  • Research Priority Alignment

    N/A

  • Research Category

    Vaccines research, development and implementation

  • Research Subcategory

    N/A

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The S-VLP project, coordinated by Winfried Weissenhorn (UMR 5075 - Institut de Biologie Structurale (IBS) - Université Grenoble Alpes / Grenoble), proposes a vaccine approach based on viral-type synthetic particles (VLP) coated with envelope glycoprotein trimeric S of SARS-CoV-2. It will focus on finalizing a pilot study through the detailed analysis of the immune response obtained and inoculation of animals with SARS-CoV-2 in order to assess the level of protection achieved, and to generate a new generation of VLP S-covered synthetics (S-VLP) where the C-terminus of the trimers will be covalently linked to lipids to avoid premature dissociation of S during immunization. It aims to produce a safe vaccine candidate, based on a proven classical approach, for further development and clinical trials.