Keeping rural minority 'essential' workplaces open safely during the COVID-19 pandemic: The role of frequent point-of-care molecular workplace surveillance for miners

ABSTRACTThere are limited studies on the spread of SARS-CoV-2 infection in rural essential workers. This gap-in-knowledge mustbe addressed to develop and implement novel pandemic strategies to keep open rural essential workplaces, such as coalmines. The long-term goal of the study is to mitigate the spread of the pandemic in miners, a population of high-risk, ruralessential workers who are susceptible and vulnerable to COVID-19, and who are predominantly racial/ethnic minorities inNew Mexico (NM). The study objective is to provide proof-of-principle for frequent point-of-care molecular testing as aworkplace surveillance tool to monitor and prevent the spread of SARS-CoV-2 infection in this unique population. Thecentral hypothesis is that frequent workplace molecular surveillance is an effective method to reduce SARS-CoV-2 infectionand discover novel host risk factors. The site of molecular surveillance (intervention site) will be a surface mine in McKinleyCounty, NM, located just outside the Navajo Nation, comprised of 66% minority miners. Miners at the intervention site willprovide nasal swabs every alternate work shift, which will be analyzed with the Abbott ID Now™ COVID-19 test, i.e., the'index' test. The control mine located at Campbell County, Wyoming, has similar mine characteristics as the interventionmine. The rationale for this study is to establish the suitability of longitudinal molecular surveillance to prevent and controlSARS-CoV-2 infection in this unique population by completing the following aims. Specific Aim 1: To determine theacceptance rate to frequent point-of-care molecular workplace surveillance among miners. Hypothesis 1: Miners will havea cumulative acceptance rate of frequent testing at ≥85%, with the added objective of exploring difference in acceptance byminer characteristics. Specific Aim 2: To determine the ability to detect the presence of SARS-CoV-2 by point-of-caremolecular workplace surveillance in a real-world setting of miners. Hypothesis 2: The sensitivity of the index test in a real-world study setting is a) comparable to that described by others in controlled settings, and b) positively associated with viralload in upper respiratory specimens. Specific Aim 3: To determine the effectiveness and implementation costs of frequentpoint-of-care molecular workplace surveillance on reducing incident infection rates of SARS-CoV-2. Hypothesis 3A:Frequent point-of-care molecular testing over six months in the intervention mine will result in lower incident seropositivityrates compared to the control mine. Hypothesis 3B: Frequent point-of-care molecular surveillance in the intervention mineis cost-effective compared to the control mine. Specific Aim 4: To determine novel predictive host factors associated withincident SARS-CoV-2 infection in miners. Hypothesis 4: Miners with incident infection demonstrate less frequent use ofcloth face coverings outside the workplace, greater mine dust exposure intensity, presence of dust-related lung disease, andracial/ethnic minority status than those not infected. Successful completion of the study will establish the acceptability andeffectiveness of the proposed surveillance in work settings where common occupational mitigation strategies are notpossible. Findings from this study will provide broad-reaching implications for novel pandemic strategies to keep ruralessential workplaces open. By working with the NIH RADx-UP Coordinating and Data Collection Center, this study willprovide crucial data for subsequent studies of vaccine interventions in rural minority essential workers.