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Roles of T follicular helper cells and tissue resident memory cells of mucosal immunity in COVID-19 disease severity

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    e-Asia JRP

  • Principal Investigator

    Associate Professor Kazuko Yamamoto, Jay Kolls

  • Research Location

    Japan, United States of America

  • Lead Research Institution

    Nagasaki University Hospital

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

In this US-Japan cooperative research project, we aim to elucidate the role of T follicular helper cells and airway tissue resident memory cells in generating protective immune response in airway mucosa during COVID-19. Synergy of our unique in vivo disease model and analysis of SARS-CoV-2 specific antibodies from patients will directly connect to the development of novel vaccine against COVID-19.