Composition of immunoglobulin CDRs: geography and coevolution with fever-inducing pathogens

Neutralization of a pathogen requires that the link between the specific antibody and the pathogen has optimal affinity. This affinity is determined by the landscape (loads and formats) of the amino acids that make up the regions that will come into contact. The pathogen can escape the host's immune system by changing these amino acids, while the host's immunoglobulin repertoire presents strategies that result in high mutation rates in the contact regions, the CDRs. The high temperatures of the fever produced during a pathology, can alter the conformation of these interface regions, improving or worsening the neutralizing capacity of an antibody. In this project, we will evaluate the amino acid composition of the CDRs regions of neutralizing antibodies against P. falciparum and SARS-CoV-2, in order to determine what is the contribution of the repertoire generated by the germ line in contrast to that obtained by affinity maturation, which occurs under the influence of the pathogen. We will compare the germline repertoires of several modern populations, distributed in different geographic locations, with those obtained from ancestral populations (Neanderthals, Denisovans, etc.). We anticipate that this project will contribute to the understanding of the co-evolution between pathogens and immunoglobulins on two fronts: (i) the influence of geography and local diseases as a selective pressure on the immunoglobulin repertoire, and (ii) the potential contribution to conformational changes in neutralizing immunoglobulins, when under a febrile episode, for the pathogenesis of malaria and COVID-19. (AU) that occurs under the influence of the pathogen. We will compare the germline repertoires of several modern populations, distributed in different geographic locations, with those obtained from ancestral populations (Neanderthals, Denisovans, etc.). We anticipate that this project will contribute to the understanding of the co-evolution between pathogens and immunoglobulins on two fronts: (i) the influence of geography and local diseases as a selective pressure on the immunoglobulin repertoire, and (ii) the potential contribution to conformational changes in neutralizing immunoglobulins, when under a febrile episode, for the pathogenesis of malaria and COVID-19. (AU) that occurs under the influence of the pathogen. We will compare the germline repertoires of several modern populations, distributed in different geographic locations, with those obtained from ancestral populations (Neanderthals, Denisovans, etc.). We anticipate that this project will contribute to the understanding of the co-evolution between pathogens and immunoglobulins on two fronts: (i) the influence of geography and local diseases as a selective pressure on the immunoglobulin repertoire, and (ii) the potential contribution to conformational changes in neutralizing immunoglobulins, when under a febrile episode, for the pathogenesis of malaria and COVID-19. (AU) with those obtained from ancestral populations (Neanderthals, Denisovans, etc.). We anticipate that this project will contribute to the understanding of the co-evolution between pathogens and immunoglobulins on two fronts: (i) the influence of geography and local diseases as a selective pressure on the immunoglobulin repertoire, and (ii) the potential contribution to conformational changes in neutralizing immunoglobulins, when under a febrile episode, for the pathogenesis of malaria and COVID-19. (AU) with those obtained from ancestral populations (Neanderthals, Denisovans, etc.). We anticipate that this project will contribute to the understanding of the co-evolution between pathogens and immunoglobulins on two fronts: (i) the influence of geography and local diseases as a selective pressure on the immunoglobulin repertoire, and (ii) the potential contribution to conformational changes in neutralizing immunoglobulins, when under a febrile episode, for the pathogenesis of malaria and COVID-19. (AU) and (ii) the potential contribution to conformational changes of neutralizing immunoglobulins, when under a febrile episode, to the pathogenesis of malaria and COVID-19. (AU) and (ii) the potential contribution to conformational changes of neutralizing immunoglobulins, when under a febrile episode, to the pathogenesis of malaria and COVID-19. (AU)