C-MORE Capturing MultiORgan Effects of COVID-19 Assessing the effects of Coronavirus Disease (COVID-19) on multiple organ systems and impact on quality of life, functional capacity and mental health

Summary: Although COVID-19 mostly affects the lungs, some people can develop damage to other organs. The symptoms of this disease can continue for months after the infection. The purpose of this study is to understand the effects of COVID-19 on the health of the lungs, heart, brain, liver and kidney and assess its effects on the quality of life, mental health and exercise capacity of affected individuals over a period of 12 months after the infection and compare these with those of people who have not had COVID-19. The researchers aim to study up to 616 patients who have been infected with COVID-19 and 62 people who have not been infected (control group) - and will use the control group as a benchmark to compare against the results of the infected group. Participants will be invited to attend up to 3 visits around three, six and twelve months after the infection. Controls who have not shown COVID-19 symptoms will attend only one visit. The visits will include magnetic resonance (MRI) (a system used in radiology to form pictures of the organs and the way they work) as well as assessments of breathing, exercise capacity and mental health. This research is organized by the Division of Cardiovascular Medicine at the University of Oxford and is funded by NIHR Oxford Biomedical Research Centre. Description: The purpose of this study is to understand the effects of COVID-19 on the health of the lungs, heart, brain, liver and kidney and assess its effects on the quality of life, mental health and exercise capacity of affected individuals over a period of 12 months after the infection and compare these with those of people who have not had COVID-19. We would like to study up to 616 patients who have been infected with SARS-CoV-2, (the virus that causes COVID-19) and 62 people who have not been infected. We will use the control group as a benchmark to compare against the results of the other group. Participants will be invited to attend up to 3 visits around three, six and twelve months after the infection. Controls who have not shown COVID-19 symptoms will attend only one visit. The visits will include magnetic resonance imaging of the lungs, heart, brain, liver and kidney as well as assessments of breathing, exercise capacity and mental health.