The double-edged role of innate immunity in SARS- CoV-2 infection: Dissecting new potential therapeutic targets | Pandemic PACT Tracker

Key facts

Disease
COVID-19
Start & end year
N/A
Known Financial Commitments (USD)
$662,349.98
Funder
Ministry of Health - Italy
Principal Investigator
Santoni Angela
Research Location
Italy
Lead Research Institution
NEUROMED
Research Priority Alignment
N/A

Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Immunity
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Unspecified
Vulnerable Population
Unspecified
Occupations of Interest
Unspecified

Abstract

9 Publications linked via Europe PMC

Last Updated:4 days ago

View all publications at Europe PMC

Neutrophils restricted contribution of CCRL2 genetic variants to COVID-19 severity.

Primary and Recall Immune Responses to SARS-CoV-2 in Breakthrough Infection.

Proteomic analysis identifies a signature of disease severity in the plasma of COVID-19 pneumonia patients associated to neutrophil, platelet and complement activation.

Strong immunogenicity of heterologous prime-boost immunizations with the experimental vaccine GRAd-COV2 and BNT162b2 or ChAdOx1-nCOV19.

Exploratory analysis to identify the best antigen and the best immune biomarkers to study SARS-CoV-2 infection.

Expansion of Myeloid Derived Suppressor Cells Contributes to Platelet Activation by L-Arginine Deprivation during SARS-CoV-2 Infection.

In-vitro evaluation of the immunomodulatory effects of Baricitinib: Implication for COVID-19 therapy.

Immunogenicity and safety of BNT162b2 COVID-19 vaccine in a chronic lymphocytic leukaemia patient.

Spike is the most recognized antigen in the whole-blood platform in both acute and convalescent COVID-19 patients.