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A Vizard for Us - in Times of Corona (additional corona related funding)

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    Volkswagen Stiftung

  • Principal Investigator

    Priv-Doz Dr Andreas Frey

  • Research Location

    Germany

  • Lead Research Institution

    Forschungszentrum Borstel

  • Research Priority Alignment

    N/A

  • Research Category

    Vaccines research, development and implementation

  • Research Subcategory

    Vaccine design and administration

  • Special Interest Tags

    N/A

  • Study Type

    Not applicable

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The main route of transmission for SARS-CoV-2 is the uptake of virus-carrying aerosol via mouth or nose. Viral spread and infection could be optimally prevented by intercepting and eliminating the pathogen through the action of virus-specific IgA at the portal of entry into the body. This project proposes an unorthodox mucosal vaccination approach that exploits the IgA feedback sampling mechanism of the mucosal immune system to induce secretion of SARS-CoV-2-specific IgA on the mucosal surfaces in order to prevent virus incorporation and disease.