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Investigating zoonotic and reverse-zoonotic transmission of SARS-CoV-2

  • Funded by Department for Environment, Food and Rural Affairs (DEFRA)
  • Total publications:3 publications

Grant number: SE0558

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Key facts

  • Disease

    COVID-19

  • Start & end year

    2020
    2021

  • Known Financial Commitments (USD)

    $129,652.74

  • Funder

    Department for Environment, Food and Rural Affairs (DEFRA)

  • Principal Investigator

    N/A

  • Research Location

    United Kingdom

  • Lead Research Institution

    Animal and Plant Health Agency (APHA)

  • Research Priority Alignment

    N/A

  • Research Category

    Animal and environmental research and research on diseases vectors

  • Research Subcategory

    Animal source and routes of transmission

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Description SARS-CoV-2 emerged in 2019, causing coronavirus disease (COVID-19) and attaining pandemic status in March 2020. The origins of the virus likely include transmission from wild animals to humans, possibly via an intermediate animal. SARS-CoV-2 has transmitted from humans to several animal species (reverse-zoonosis), with animal-to-animal infection (reservoir) and zoonotic (animal-to-human) transmission in some instances (e.g. captive mink). However, uncertainty around transmission parameters for SARS-CoV-2 in the zoonotic and reverse-zoonotic context, and the spectrum of host range, remain to be fully elucidated.This proposal is a progression from our initial infection model investigations (SE0557) and will synergise, utilise and expand, on two SARS-CoV-2 Defra toolbox initiation projects. The overall aim is to further our understanding of zoonotic and reverse-zoonotic potential of SARS-CoV-2 infection Objective SARS-CoV-2 emerged in 2019, causing coronavirus disease (COVID-19) and attaining pandemic status in March 2020. The origins of the virus likely include transmission from wild animals to humans, possibly via an intermediate animal. SARS-CoV-2 has transmitted from humans to several animal species (reverse-zoonosis), with animal-to-animal infection (reservoir) and zoonotic (animal-to-human) transmission in some instances (e.g. captive mink). However, uncertainty around transmission parameters for SARS-CoV-2 in the zoonotic and reverse-zoonotic context, and the spectrum of host range, remain to be fully elucidated.This proposal is a progression from our initial infection model investigations (SE0557) and will synergise, utilise and expand, on two SARS-CoV-2 Defra toolbox initiation projects. The overall aim is to further our understanding of zoonotic and reverse-zoonotic potential of SARS-CoV-2 infection

Publicationslinked via Europe PMC

Last Updated:an hour ago

View all publications at Europe PMC

Infectious droplet exposure is an inefficient route for SARS-CoV-2 infection in the ferret model.

Subclinical hepatitis E virus infection in laboratory ferrets in the UK.

Differential susceptibility of SARS-CoV-2 in animals: Evidence of ACE2 host receptor distribution in companion animals, livestock and wildlife by immunohistochemical characterisation.