Development of colorimetric sensors based on gold nanoparticles for the detection of SARS-CoV2
- Funded by National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)
- Total publications:0 publications
Grant number: COV20_00122
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Key facts
Disease
COVID-19Funder
National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)Principal Investigator
Rodolfo Miranda SorianoResearch Location
SpainLead Research Institution
Fundación Instituto Madrileño de Estudios Avanzados en Nanociencia (IMDEA-Nanociencia)Research Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Diagnostics
Special Interest Tags
Innovation
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
The project addresses the preparation of colorimetric sensors based on nanoparticles and oligonucleotides, which allow detecting the presence of the virus by means of a change in the color of a solution, or the presence of color in a nitrocellulose strip. The system will be implemented in 3 different amplification systems in order to reduce the use of equipment, highly specialized personnel and reagents to a minimum: 1) in RT-PCR, avoiding the use of qRT-PCR, 2) in isothermal amplification, avoiding the use of PCR in general, and 3) in non-enzymatic amplification, avoiding the use of enzymes. The processes developed are industrially scalable, and it is expected to rapidly acquire the capacity at IMDEA Nanoscience to produce 5,000 nanoparticle-based sensors weekly.