Nanosensor-based diagnosis and rapid identification in solution of disruptors of the interaction of the SARS-Cov-2 virus with its cellular receptor (NANOCOMPETE)

There are few serological tests against SARS-Cov-2 and none that can be performed in solution. The proposed assay makes it possible to detect antibodies (Ab) and / or viruses from serum or plasma, without processing, and directly identify Acs that compete for the virus / receptor interaction (whose sera may be used in serum therapy). We will use samples from the identified patients to identify coding sequences for Acs variable regions with sufficient affinity to block virus / receptor interaction and we will develop CARs for the destruction of infected cells but regulatory CARs to specifically block the immune system, in those cases in which it is responsible for the pathogenesis of serious infections. Based on existing developments, we proposed the proof of concept of a nanosensor, which allows the analysis of samples by the general public and the sending of results by means of a smartphone.