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Role of NK cells in the susceptibility and prognosis of SARS-CoV2 (COVID19) infection

  • Funded by National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)
  • Total publications:0 publications

Grant number: COV20_00377

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)

  • Principal Investigator

    ENRIQUE BERNAL MORELL

  • Research Location

    Spain

  • Lead Research Institution

    FUNDACION PARA LA FORMACION E INVESTIGACION SANITARIAS DE LA REGION DE MURCIA (FFIS)

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The project investigates the role of NK cells in the susceptibility and prognosis of SARS-CoV2 (COVID19) infection. In patients with mild (n = 100) and severe (n = 100) disease, the genotype (PCR-SSO-Luminex) and the expression in NK cells (12 Fluorescence cytometry) of the KIR / ligand-HLA-I interactions that regulate the education and function of these cells and determine their effectiveness against viral infections. The data will be contrasted with 600 healthy controls of known genotype. The results would contribute to optimizing health resources and avoiding collapse by facilitating: 1) accentuating protection efforts in the most susceptible people (health professionals, law enforcement officials, relatives of the sick, etc); and 2) anticipate anti-viral and anti-inflammatory therapies at the appearance of the most serious symptoms in susceptible patients.