Identification of the dynamic transcripomic profile in patients with COVID-19 and acute respiratory distress syndrome (TRANSCOVID)

Although some clinical characteristics (advanced age, high fever, SOFA) and inflammatory response (IL-6, PC-R, D-dimer) have been described, the reasons why certain patients with COVID-19 develop severe disease, presenting dyspnea and hypoxemia in the first 7 days and rapid progression to ARDS, multiple organ failure and death, they still remain an enigma. The main objective of this project is to determine the dynamic transcriptomic profile of adult patients hospitalized for COVID-19 and to characterize the subgroup that develops severe disease (ARDS). Secondary objectives are to establish a gene signature capable of basal discrimination of the group that will develop ARDS and contribute to the phylogeny of the virus.