An innovative therapy against Covid-19 based on circular RNAs
- Funded by National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)
- Total publications:0 publications
Grant number: COV20_00183
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Key facts
Disease
COVID-19Funder
National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)Principal Investigator
JUANA DÍEZ ANTÓNResearch Location
SpainLead Research Institution
Universidad Pompeu FabraResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen morphology, shedding & natural history
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
Given the speed with which we can sequence the genomes of new RNA viruses, developing targeted therapies against them, rather than against viral proteins, would accelerate the development of efficient therapies. In this project we will generate and validate, in cell culture and in mouse models, circular RNAs (ARNcircs) that hybridize and interfere with essential structures in the SARS-CoV-2 genome and inactivate it. The selection of resistances is highly unlikely given the conservation of the target sequences and the interference on several regions simultaneously. Our previous success with ARNcircs that inhibit the replication of other RNA (+) viruses, and the existence of RNA-based therapies already in the clinic and of nebulization delivery systems, support the viability of our proposal.