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Epidemiological study and clinical-molecular implications of angiotensin in the prognosis of SARS-Cov-2 infection

  • Funded by National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)
  • Total publications:0 publications

Grant number: COV20_00421

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Key facts

  • Disease

    COVID-19

  • Funder

    National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)

  • Principal Investigator

    Maria Sonia Gaztambide Saénz

  • Research Location

    Spain

  • Lead Research Institution

    Instituto de Investigación Sanitaria Biocruces Bizkaia

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Epidemiological study and expression of polymorphisms in patients with COVID-19 infection under treatment with ACEI or AIIRA. The aim is to establish the association and the impact between COVID-19 infection and chronic treatment with ACEI or AIIRA, in terms of a torpid-fatal clinical course. These drugs increase the expression of ECA2, a vehicle for entry to target cells in SARS CoV / SARS CoV-2 acute respiratory syndrome. The aim is to establish the relationship between viral load and genetic predisposition by identifying polymorphisms and their expression linked to this enzyme, related to diseases such as: diabetes, hypertension and stroke and their treatments; trying to develop clinical trials to identify more efficient therapies in a population with high mortality.