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Study of the SARS-CoV-2 viral load in the respiratory tract and blood as a factor associated with the prognosis of COVID-19 in adults

  • Funded by National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)
  • Total publications:0 publications

Grant number: COV20_00580

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)

  • Principal Investigator

    Javier Sánchez Céspedes

  • Research Location

    Spain

  • Lead Research Institution

    Fundación Pública Andaluza para la Gestión de la Investigación en Salud de Sevilla (FISEVI)

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Diagnostics

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The general objective is to analyze the influence of the SARS-CoV-2 viral load in the lower respiratory tract (sputum or invasive samples if its study is indicated), as well as in blood and feces as indicators of disseminated disease, as factors associated with development of pneumonia and the evolution of the disease, measured by the need for assisted ventilation and cure or death. Virological variables will be included in an analysis along with demographic variables, comorbidities, and clinical and radiological characteristics of pneumonia. Also, the sensitivity of SARS-CoV-2 RT-PCR in nasopharyngeal smears will be evaluated. sputum and viremia. Finally, the excretion and infectivity of the virus in feces will be determined after the patients are cured.