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Immunological and virological factors in COVID-19 and their correlation with the evolution to severe forms of the disease.

  • Funded by National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)
  • Total publications:0 publications

Grant number: COV20_00943

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)

  • Principal Investigator

    Mercedes García Gasalla

  • Research Location

    Spain

  • Lead Research Institution

    FUNDACION INSTITUTO DE INVESTIGACION SANITARIA ILLES BALEARS

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Prospective study to be carried out at the Son Espases and Son LLátzer Hospitals in Palma de Mallorca, the objective of which is to identify virological and immunological factors, as well as clinical, radiological and analytical factors, related to severe forms of COVID-19. During the months of April and May 20120, 150 patients diagnosed with mild, severe and moderate COVID-19 will be recruited (50 patients in each group) and determinations will be made in peripheral blood of baseline levels and at 2 weeks of IL1, IL6, IL8, IL10, TNFa and IL2R, of lymphocyte subpopulations and complement study, as well as study of semiquantitative viral load in oropharynx and peripheral blood and production of Ab against SARS-COV-2. The relationship of these parameters with epidemiological, clinical and radiological variables of mild, severe and moderate COVID-2 will be analyzed.