Study for the identification of cytokine profiles capable of predicting the development of respiratory distress secondary to infection by coronavirus 2 (SARS-CoV-2))

We will carry out, for a week, daily blood draws from a cohort of 100 patients currently admitted to the HM Sanchinarro Hospital with a confirmed or highly suspected diagnosis of COVID-19. A broad panel of cytokines (LUMINEX) will be determined in these samples, prospectively correlating the analytical results with the development of severe SARS. Using computer algorithms, we will establish the determinations that best predict the appearance of this complication. The analysis will focus on proteins included in the portfolio of commercial companies that produce, on an industrial scale, diagnostic kits using ELISA. Thus, the markers found will be immediately available at any healthcare center in the country. In parallel, we will study the interindividual genetic variability and the evolution of the viral load in these cases. In a second phase we will develop more precise and patentable multiplex kits.