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ASSESSMENT OF THE SPECIFIC IMMUNE RESPONSE TO SARS-CoV-2

  • Funded by National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)
  • Total publications:0 publications

Grant number: COV20_00508

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Key facts

  • Disease

    COVID-19

  • Funder

    National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)

  • Principal Investigator

    RAMON GIMENO MARTINEZ

  • Research Location

    Spain

  • Lead Research Institution

    Fundacio Institut del Mar dÇîInvestigacions Mediques

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Other

  • Occupations of Interest

    Unspecified

Abstract

The control of SARS-CoV-2 infection is based on the development of an effective immune response against the virus and on the appearance and maintenance of memory T lymphocytes that can be activated if the virus reappears. The generation of memory T lymphocytes is also necessary to ensure the efficacy of vaccination strategies. Using cellular techniques (ELISPOT, flow cytometry) we will study the characteristics of the immune response in patients who have resolved the infection, regardless of its clinical manifestations. In addition, we will analyze the evolution of the infection and the immune response in patients with chronic inflammatory diseases to study whether the immunosuppressive treatments (biological or pharmacological) could have had any positive or negative impact on the course of the infection and on the establishment of immunological memory.