Study of the immune response in nested cases in a cohort to evaluate the effect of antiretrovirals on the evolution of the SARS-COV-2 coronavirus infection.

Patients infected with the CoVid-19 virus are characterized by a high degree of inflammation and dysregulation of the specific T response. In studies carried out with patients from the Hospital Universitario La Paz with respiratory diseases, we have found that the hypoxia and oxidative stress suffered by these patients cause the inflammasome complex to be activated. This complex also has effects on pyroptosis and on the production of type I IFNs. On the other hand, the inflammatory condition of the patient will directly condition the specific T response. In short, understanding the inflammatory state in patients provides relevant information on the evolution of the pathology. The aim of this project is to study the effect of the drugs included in this clinical trial in patients with CoVid-19, on the activation of the inflammasome and its effect on inflammation and the T response. These data associated with the evolution of the patient are determinants to classify responding patients and mechanisms of viral evasion.