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Identification and Characterization of the Protective T Immune Response Against SARS-CoV-2: Successfully Guiding Vaccine Design

  • Funded by National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)
  • Total publications:0 publications

Grant number: COV20_00660

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Key facts

  • Disease

    COVID-19

  • Funder

    National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)

  • Principal Investigator

    JULIA GARCÍA PRADO

  • Research Location

    Spain

  • Lead Research Institution

    INSTITUTO DE INVESTIGACIÇÿN DEL SIDA IRSICAIXA

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Not applicable

Abstract

At present we do not know if the SARS-CoV-2 infection will be able to generate immunological memory at the population level. The presence of immunological memory T is essential for the control of a new CoV-2 epidemic outbreak. Under these premises, this project proposes: 1) Identify the CoV-2 regions recognized by the immune T response associated with protection. 2) Determine the generation time of these responses. 3) Characterize the functionality of the T responses associated with protection against CoV-2. This information is essential to successfully design and evaluate the immunogenicity of a new prototype T vaccine in a second phase. The ultimate goal is to achieve prolonged population protection against SARS-CoV-2 through vaccination.