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Disruption of viral transport processes mediated by microtubules

  • Funded by National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)
  • Total publications:0 publications

Grant number: COV20_01007

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Key facts

  • Disease

    COVID-19

  • Funder

    National Institute of Health Carlos III [El Instituto de Salud Carlos III] (ISCIII)

  • Principal Investigator

    JOSÉ FERNANDO DIAZ PEREIRA

  • Research Location

    Spain

  • Lead Research Institution

    AGENCIA ESTATAL CSIC CENTRO DE INVESTIGACIONES BIOLÇÿGICAS

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

SARS-CoV-2 depend on microtubules for its internalization and release process, therefore microtubules can constitute an effective target to stop its replication. since they are involved in important cellular processes essential for growth and proliferation, essential for viral replication. Tools are available to visualize the movement of microtubule transporters attached to viral model peptides and thus evaluate their response to miniscule concentrations of drugs as well as the world's largest library of drugs directed against tubulin. The library will be screened in the evaluation system developed looking for drugs that inhibit this transport and viral replication at tolerable doses.