Inborn errors of Immunity and predisposition to infection by SARS-Cov-2 and the severity of COVID-19. International coordinated action. Full exomic sequencing. (project 1)

SARS-Cov-2 infection is mild or even asymptomatic in many patients, but it can cause severe illness (COVID-19), mainly in patients older than 50 years, especially those with comorbidities. There are, however, young patients without risk factors with severe forms of the disease. Some of these patients may have inborn errors of immunity (diseases often with incomplete penetrance). The main objective is the sequencing of the complete exome, using massive sequencing techniques, in patients under 50 years of age in the Spanish territory without comorbidities or risk factors. The project is part of an international consortium, of which we are one of the participating groups (https://www.cvidhge.com), in which information will be shared to carry out population studies that allow progress towards precision medicine in patients with COVID-19.