Identifying Effective Mental Health Interventions and Populations in Need: A COVID-19 Living Systematic Review

  • Funded by Canadian Institutes of Health Research (CIHR)
  • Total publications:9 publications

Grant number: 173070

Grant search

Key facts

  • Disease

    COVID-19
  • Start & end year

    2020
    2021
  • Known Financial Commitments (USD)

    $152,874.54
  • Funder

    Canadian Institutes of Health Research (CIHR)
  • Principal Investigator

    Brett D Thombs
  • Research Location

    Canada
  • Lead Research Institution

    Lady Davis Institute for Medical Research
  • Research Priority Alignment

    N/A
  • Research Category

    Secondary impacts of disease, response & control measures

  • Research Subcategory

    Indirect health impacts

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

There will be serious mental health implications from COVID-19 that extend beyond the first outbreak for many people. Addressing mental health needs requires understanding the nature and extent of mental health ramifications, factors associated with vulnerability, and evidence on effectiveness of interventions that may be rapidly employed to prevent or address mental health concerns. Studies from COVID-19 are published rapidly, but many are of dubious quality. Thus, curation of this growing evidence base is urgently needed to provide practitioners and policy makers with clear, coherent evidence synthesis. Living systematic reviews are systematic reviews that are continually updated and provide ongoing access to results via online publication. They are logistically challenging, but provide value beyond conventional systematic reviews in situations where (1) important decisions need to be made; (2) uncertainty in existing evidence poses a barrier to decision-making; and (3) new evidence is emerging rapidly. Such a review is urgently needed to guide mental health care during and following COVID-19. Our research team has expertise in high-impact evidence synthesis research (https://www.depressd.ca/teammembers). Our protocol has been made public on the Open Science Framework (https://osf.io/96csg/). An editorial on the project has been published and will be indexed in major search databases to announce that the living systematic review will provide ongoing, rigorous curation of COVID-19 mental health evidence. We have already launched initial database searches, are receiving daily search updates, and have already reviewed > 12,000 articles. We have published initial evidence online (https://www.depressd.ca/covid-19-mental-health). Important evidence will be published in the months to come. It is crucial to maintain funding for this important project to incorporate the higher quality evidence that is beginning to be made available.

Publicationslinked via Europe PMC

NEDD4 Promotes Sertoli Cell Proliferation and Adult Leydig Cell Differentiation in the Murine Testis.

The <i>-KTS</i> splice variant of WT1 is essential for ovarian determination in mice.

Single-cell transcriptomic profiling redefines the origin and specification of early adrenogonadal progenitors

Base-Exchange Enabling the Visualization of SARM1 Activities in Sciatic Nerve-Injured Mice.

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonad.

Single-cell transcriptomics identifies potential cells of origin of MYC rhabdoid tumors.

Specific Transcriptomic Signatures and Dual Regulation of Steroidogenesis Between Fetal and Adult Mouse Leydig Cells.

The Insulin/IGF System in Mammalian Sexual Development and Reproduction.

ZNRF3 functions in mammalian sex determination by inhibiting canonical WNT signaling.