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Accelerated Artificial Intelligence Strategy for Drug Repositioning and Discovery for Covid-19

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    FAPEG Brazil

  • Principal Investigator

    Carolina Horta Andrade

  • Research Location

    Brazil

  • Lead Research Institution

    UFG

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Presented by Carolina Horta Andrade (UFG), a study seeks to reposition drugs already approved for use in humans and to identify new drug candidates for the treatment of Covid-19 with the potential for rapid clinical development. The studies will be carried out through a multidisciplinary approach that will involve the development and application of artificial intelligence tools, virtual screening assays, enzymatic and biophysical assays, antiviral activity tests in cell culture in a level 3 biological containment laboratory, structural characterization of the complexes protein-ligand, synthesis and optimization of analogues, for the identification of effective compounds useful in the treatment of Covid-19