Identification of cellular and molecular immunological components associated with Covid-19: perspectives for therapeutic and vaccine strategies

Presented by Simone Gonçalves da Fonseca (UFG), the proposal aims to evaluate the profile of cytokines, chemokines and growth factors in plasma or serum of individuals infected with SARS-CoV-2, with different clinical forms in relation to uninfected control individuals. The study also seeks to: evaluate the phenotypic profile of subpopulations of T lymphocytes, B lymphocytes, monocytes, and cell activation in individuals infected by SARS-CoV-2 with different clinical forms in relation to uninfected control individuals; investigate whether there is a differential functional profile of the antigen-specific immune response, directed to SARS-CoV-2 antigens in infected individuals, with different clinical forms in relation to uninfected control individuals; to characterize the transcriptomic profiles in peripheral blood or peripheral blood mononuclear cells and the metabolomic profiles in plasma, urine or other body fluids of infected individuals and non-infected controls; and perform the analysis and integration of the data generated in the study.