Natural History of Infection with the new coronavirus (2019- nCoV) in patients from vulnerable areas in the Federal District

The emergence and reemergence of infectious diseases must compose the main agendas in the agendas of Public Health policies in Brazil, mainly due to peculiarities that mark the country's territoriality and population: its continental size, heterogeneous demographic density and the great majority of people without access to services basic health, such as environmental sanitation. In the current context of the COVID-19 pandemic (Coronavirus Disease 2019), this branch of Public Health is rescued with high urgency according to the speed of transmission and the number of deaths from the disease, with magnitudes greater than the outbreaks and pandemic observed in previous years, caused by infectious agents transmitted by airways and fomites (SARS in 2002-2003; H1N1 in 2009-2010; MERS in 2013). There are new challenges in intervention and control measures, such as social isolation, identification of suspected and asymptomatic cases on a large scale by laboratory criteria, and availability of beds in intensive care unit beds for severe cases. This project aims to develop community-based sentinel syndromic surveillance in a vulnerable community in the Federal District for Severe Acute Respiratory Syndrome (SARS), which is being possible within the infectious spectrum of COVID-19, caused by the coronavirus SARS-CoV-2. For this, sentinel syndromic surveillance will be developed in the Basic Health Unit 01 of Estrutural, aiming at the main stages of patient flow, such as screening, clinical diagnosis, laboratory diagnosis and monitoring of diseases. For laboratory confirmation, according to the moment of sample collection, RT-PCR will be performed in an acute situation (when the patient goes to the emergency room complaining of symptoms), and serological IgM / IgG for subsequent viremic period and follow-up of the condition; concomitantly, local health professionals will also be monitored for a possible biological risk rate for the location. It is intended, with the results of this study: to designate the epidemiological profile of COVID-19 in a vulnerable area; improve epidemiological surveillance for severe respiratory syndromes; improve safety levels and health protocols for the flow of patients for the disease; production of scientific-technological framework (incubation period; clinical-epidemiological spectrum; risk factors for severity); accuracy of clinical-epimiological and laboratory diagnostics (rapid and bench); measure biological risk,