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Design of clinical trials for COVID-19 therapies

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    Yale University

  • Principal Investigator

    David Paltiel

  • Research Location

    United States of America

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    N/A

  • Special Interest Tags

    N/A

  • Study Type

    Not applicable

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

A simple epidemic/queuing model demonstrates that even small therapeutic effects will have an outsize impact on both overall mortality and the number of person-days with critical illness. We develop a simple framework to assist investigators in designing, evaluating, and appropriately powering new trials to identify these very small effects.