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Active Ingredient Screening For Drugs Against Covid-19

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Key facts

  • Disease

    COVID-19

  • Principal Investigator

    Dr and Dr and Dr and Prof and Prof and Dr Boris Fürtig, Martin Hengesbach, Andreas Schlundt, Jens Wöhnert, Harald Schwalbe, Julia Weigand
    …

  • Research Location

    Germany

  • Lead Research Institution

    Center for Biomolecular Magnetic Resonance (BMRZ)

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Rapidly identifying new active ingredients against SARS-CoV-2 and other corona viruses is difficult - for both basic and translational research. The NMR COVID-19 project aims to accelerate this process through nuclear magnetic resonance spectroscopy (NMR). The international team of more than 200 scientists led by Prof. Dr. Harald Schwalbe from the Center for Biomolecular Magnetic Resonance (BMRZ) determines the three-dimensional structure of all RNAs and proteins of SARS-CoV-2 viruses in this process. All viral RNAs and proteins are screened with potential active ingredients to find out whether known active ingredients bind to virus molecules and, in particular, to find new active ingredients. "Thanks to global scientific networking, we can find COVID-19 vulnerabilities for effective therapies more quickly."