Strengthen Immune Memory

A project at the Frankfurt University Hospital is investigating how the immune response of COVID-19 patients changes in the course of the disease at the level of the immune cells. The most modern sequencing methods at the single cell level are used for this. Patients with a milder course of the disease are compared with those who suffer a severe course of the disease and, in turn, those who received the active ingredient "Remdesivir" as part of a study. The Goethe Corona Fund is supporting the project with start-up funding, as a promising application for research funding has been submitted to the Federal Ministry of Research. "We hope that the project will provide a unique overview of the critical changes in the immune system during the course of the disease, and to understand which processes in patients lead to a life-threatening course of the COVID-19 infection." Prof. Dr. Michael Rieger "These findings are decisive for the development of new therapy concepts, the aim of which is to modulate the immune response of COVID-19 patients in such a way that, after the disease has healed, an immune memory is created that provides long-term protection against COVID-19 disease. " Prof. Dr. Evelyn Ullrich