Return to homepagePandemic Pact

No title

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $0

  • Funder

    Chan Zuckerberg Initiative

  • Principal Investigator

    Alexandra-Chloe Villani, Orit Rozenblatt-Rosen

  • Research Location

    United States of America

  • Lead Research Institution

    Broad Institute of MIT and Harvard

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Immunity

  • Special Interest Tags

    N/A

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Researchers will investigate the host immune and cellular response associated with COVID-19 infection, symptoms, and lethality. This project is being done in close collaboration with several investigators and clinicians at the Massachusetts General Hospital and the Brigham and Women's Hospital to use single-cell genomic pipelines to analyze 500 longitudinal blood samples from COVID-19 patients collected in the hospital setting, as well as tissue samples (lung, heart, liver) from 10 deceased patients. Data will be rapidly shared as de-identified datasets with the biomedical community, and researchers will work closely with experts to analyze the results to inform disease outcomes in COVID-19 patients.