COVID-19 First Few Hundred (FFX) study

Understanding secondary infection rate for household contacts and factors associated with variation in secondary infection risk. What is the issue? Understanding the factors and variation associated with secondary infection rates for household contacts will provide important insights and influence policy recommendations on the management of cases in household contacts. Any impact of changes in policy will be able to be monitored in real time with data collection and interim analyses continuing throughout the study period. What does the research aim to do and how? The study will estimate the secondary infection rate for household contacts at an individual level, and factors associated with any variation in the secondary infection risk. The study also aims to characterize secondary cases including the range of clinical presentation, risk factors for infection, and the extent and fraction of asymptomatic infections The study, which is funded and led by the University of Melbourne and the Australian Partnership for Preparedness Research on Infectious Disease Emergencies (APPRISE), involves collaboration among various partners, including, but not limited to, the Australian Government Department of Health, NSW Health, WA Health, SA Health, Royal Children's Hospital, Melbourne.