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COVID-19 SMILES - the study of vaccine escape mutants

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    BC Ministry of Health

  • Principal Investigator

    Unspecified Agatha Jassem

  • Research Location

    Canada

  • Lead Research Institution

    University of British Columbia, BC Centre for Disease Control

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen genomics, mutations and adaptations

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Vaccine escape mutants have the potential to undermine the effectiveness of the global vaccination campaign against SARS-CoV-2. The team will develop a surveillance program to detect and sequence viral variants emerging from vaccine breakthrough infections. These mutants will be tested experimentally to understand their responsiveness to vaccine-induced immunity, and modeling will be incorporated to project the impacts of vaccine escape mutants on transmission and pandemic progression in BC.