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Using lab-grown human tissues to identify possible treatments

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Principal Investigator

    Dr. William Stanford

  • Research Location

    Canada

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Pathogen morphology, shedding & natural history

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Unspecified

Abstract

Dr. William Stanford and his colleagues are using human tissue models to understand why COVID-19 makes some patients severely ill. They also hope to identify and test new drugs that can reduce the severe lung damage that typically kills people with COVID-19. First, they will rapidly test two cellular pathways involved in causing this lung damage. Then they will rapidly screen for drugs that have already been approved by Health Canada and the FDA that are able to block these pathways, and potentially reduce disease severity and death. Their research may also reveal biomarkers that can identify which patients with COVID-19 are most likely to require intensive care.