Creating a new mouse model to study COVID-19 lung disease
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Key facts
Disease
COVID-19start year
-99Known Financial Commitments (USD)
$0Principal Investigator
Dr and Dr Manoj and Duncan Lalu and StewartResearch Location
CanadaLead Research Institution
N/AResearch Priority Alignment
N/A
Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Disease models
Special Interest Tags
N/A
Study Type
Unspecified
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable
Abstract
Drs. Manoj Lalu, Duncan Stewart and colleagues are working to develop a mouse model of COVID-19 that mimics the severe lung disease seen in humans. The lack of good, accessible animal models of this disease is severely limiting research around the world. The COVID-19 virus doesn't infect regular lab mice very well, and the virus is dangerous to work with because it is so contagious for humans. Drs. Lalu are Stewart are working with Drs. Carolina Ilkow and John Bell, who are creating a novel hybrid virus that features a key protein from the COVID-19 virus (the spike protein) embedded into a well-studied and safe virus called vesicular stomatitis virus (VSV). The team will test this hybrid virus in mice that have been genetically engineered to be more susceptible to COVID-19, to mimic the severe lung disease seen in humans.