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Using data from the Duke Health Pathology Biorepository, we will develop a cohort of clinically available data and specimens from obese patients admitted with COVID-19 to assess for metabolic syndrome, use blood samples to genotype patients for single nucleotide polymorphisms in genes associated with abnormal lipid metabolism and increased oxidative stress, and determine significant associations between these polymorphisms and/or metabolic syndrome with use of non-invasive ventilation, mechanical ventilation or tracheostomy in obese patients with COVID-19 pneumonia. Using that same cohort, we will also obtain clinically available markers of systemic inflammation, assay blood samples for tumor necrosis factor alpha (TNF-α), leptin, adiponectin and glutathione to glutathione disulfide ratio (GSH/GSSG), and quantify the association between these polymorphisms, metabolic syndrome, obesity, and systemic inflammation.