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Production of pseudotyped SARS-CoV-2 in BSL-2 setting using vesicular stomatitis virus VSV platform for candidate vaccine development and biomedical research use

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    BIRAC

  • Principal Investigator

    Debasis and Akansha Nayak and Chaturvedi

  • Research Location

    India

  • Lead Research Institution

    Indian Institute of Technology Indore

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Diagnostics

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

This proposal aims to generate a replication-deficient pseudovirus containing SARS-CoV2 virus spike protein for developing candidate vaccine and other biomedical research use. The proposed VSV glycoprotein deleted VSV?G platform containing immunodominant SARS-CoV-2 S protein aims to elicit an adequate humoral immune response in the murine host. Although our initial plan is to develop this reagent to use it as a candidate vaccine in human as well in animal hosts, the same will be available for other biomedical research use like i study-virus entry, ii neutralizing antibody response, iii diagnostic use in antigen coating in ELISA plate development, iv monoclonal antibody development, and v drug discovery and screening purpose, etc.