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A novel vaccine evaluation platform to support SARS-CoV-2 vaccine development in resource-limiting settings

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    BIRAC

  • Principal Investigator

    Nimesh Gupta

  • Research Location

    India

  • Lead Research Institution

    National Institute of Immunology, New Delhi

  • Research Priority Alignment

    N/A

  • Research Category

    Pathogen: natural history, transmission and diagnostics

  • Research Subcategory

    Disease models

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

The aim is to provide the human ACE2 expressing animal model for pre-clinical vaccine evaluation and to develop the Tcell and B-cell based assays that would test the immunogenicity, quality and stability of protective immune response to a SARS-CoV-2 vaccine candidate. Moreover, SARS-CoV-2 Pseudotyped virus has been developed for vaccine evaluation in BSL-2 settings.