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Virus Capsids

  • Funded by Paul Scherrer Institut (PSI)
  • Total publications:0 publications

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Funder

    Paul Scherrer Institut (PSI)

  • Principal Investigator

    Unspecified Unspecified Unspecified

  • Research Location

    Switzerland

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Vaccines research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    N/A

  • Study Type

    Non-Clinical

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Not Applicable

  • Vulnerable Population

    Not applicable

  • Occupations of Interest

    Not applicable

Abstract

Roger Benoit at the Laboratory for Nanoscale Biology (LNB) is specialized in structure-based protein engineering. Virus capsids are symmetric shells enclosing the viral genome. They are typically built from multiple copies of one or a few protein components. The capsids of many viruses can be produced alone, without viral genetic material. Their component proteins can be genetically fused to peptidic or proteinaceous epitopes of any virus, making them useful as self-assembling immunization agents or as tools for the development of novel virus detection methods. The team of Roger Benoit has developed special protein-protein linkers to produce nanoparticles that display SARS-2-CoV-19 epitopes at specific angles and spacings, to optimize immunogenicity.