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COVID-19-induced vascular complications: mechanisms and potential therapies

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:2 publications

Grant number: 2010757

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Known Financial Commitments (USD)

    $531,379.54

  • Funder

    National Health and Medical Research Council (NHMRC)

  • Principal Investigator

    Dr. Emma Gordon

  • Research Location

    Australia

  • Lead Research Institution

    University of Queensland

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Disease pathogenesis

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

The coronavirus SARS-CoV-2 is responsible for the disease COVID-19, which causes significant lung dysfunction. Importantly, reports have observed COVID-19 symptoms that are not associated with the lungs, such as blood clots, vessel inflammation and leakage of fluid from vessels into tissues. These virus-induced vessel defects can lead to the death of patients. Here, we aim to understand exactly how these vessel defects occur to develop treatments for patients with acute and long term disease.

2 Publications linked via Europe PMC

Last Updated:4 days ago

View all publications at Europe PMC

Dengue virus NS1 protein does not activate TLR4 and has a modest effect on endothelial monolayer integrity compared to TNF.

Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells.