COMBAT - A Combination B-and T-Cell Epitope Vaccine to Futureproof COVID-19 Vaccine

  • Funded by National Health and Medical Research Council (NHMRC)
  • Total publications:11 publications

Grant number: 2011044

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Key facts

  • Disease

    COVID-19
  • Known Financial Commitments (USD)

    $897,133.25
  • Funder

    National Health and Medical Research Council (NHMRC)
  • Principal Investigator

    Dr. Manisha Pandey
  • Research Location

    Australia
  • Lead Research Institution

    Griffith University
  • Research Priority Alignment

    N/A
  • Research Category

    Vaccines research, development and implementation

  • Research Subcategory

    Clinical trial (unspecified trial phase)

  • Special Interest Tags

    Innovation

  • Study Type

    Unspecified

  • Clinical Trial Details

    N/A

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

We are proposing a vaccine that contains only safe components of the SARS-CoV-2 virus, yet effectively elicits protective immunity. The vaccine works by inducing antibodies capable of preventing the virus from attaching to lung cells, and killer T cells that destroy virus-infected cells. This highly innovative approach will generate a much needed safe and prophylactic 2nd generation modular vaccine, ideal for "vaccine update" that will have a major impact on health and society more generally.

Publicationslinked via Europe PMC

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View all publications at Europe PMC

The effects of sympathetic nerve damage on satellite glial cells in the mouse superior cervical ganglion.

Cholinergic responses of satellite glial cells in the superior cervical ganglia.

The effects of endothelin-1 on satellite glial cells in peripheral ganglia.

Gap junctions, pannexins and pain.

Long term effects of lipopolysaccharide on satellite glial cells in mouse dorsal root ganglia.

Involvement of aberrant calcium signalling in herpetic neuralgia.

Systemic inflammation activates satellite glial cells in the mouse nodose ganglion and alters their functions.

Satellite glial cells in dorsal root ganglia are activated in streptozotocin-treated rodents.

Role of satellite glial cells in gastrointestinal pain.