Predicting and preparing for the unfolding evolution of SARS-CoV-2

Key facts

Disease
COVID-19
Start & end year
N/A
Known Financial Commitments (USD)
$740,678.51
Funder
National Health and Medical Research Council (NHMRC)
Principal Investigator
Prof. Alexander Khromykh
Research Location
Australia
Lead Research Institution
University of Queensland
Research Priority Alignment
N/A

Research Category
Pathogen: natural history, transmission and diagnostics
Research Subcategory
Pathogen genomics, mutations and adaptations
Special Interest Tags
N/A
Study Type
Non-Clinical
Clinical Trial Details
N/A
Broad Policy Alignment
Pending
Age Group
Not Applicable
Vulnerable Population
Not applicable
Occupations of Interest
Not applicable

Abstract

One year on from the emergence of the COVID-19 pandemic, variants of SARS-CoV-2 have evolved to be more transmissible, pathogenic and less susceptible to immune responses from infection or vaccination. We propose utilising the deep mutational scanning method to examine the molecular pathogenesis and vaccine escape of SARS-CoV-2 at a single amino acid residue resolution and towards developing a universal vaccine candidate to neutralise all potential future SARS-CoV-2 variants.