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THE BABIES. Pregnant women with positive SARS-CoV-2: clinical-laboratory evolution, transplacental passage, gestational and neonatal outcomes

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    University of São Paulo

  • Principal Investigator

    Unspecified Rossana Pulcinelli and Maria and Maria Augusta and Werther Brunow and Paulo Hilário and Esper Vieira Francisco and de Lourdes Brizot and BC Gibelli and de Carvalho and Nascimento Saldiva and Kallás

  • Research Location

    Brazil

  • Lead Research Institution

    N/A

  • Research Priority Alignment

    N/A

  • Research Category

    Clinical characterisation and management

  • Research Subcategory

    Prognostic factors for disease severity

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Adults (18 and older)

  • Vulnerable Population

    Pregnant women

  • Occupations of Interest

    Unspecified

Abstract

The consequences of COVID-19 in pregnancy are not yet clear. We propose a prospective study including pregnant women with symptoms or positive serology for SARS-CoV-2 who consent to participate in the study. Cases that do not confirm maternal SARS infection will be excluded. Data regarding personal and obstetric history, previous illnesses, complications in the current pregnancy, gestational age at diagnosis of SARS-CoV-2, pregnancy evolution, laboratory results of blood count and others depending on the condition, results of ultrasound exams and fetal vitality , delivery results, neonatal results will be collected. Vertical transmission will be evaluated through the investigation of SARS-CoV-2 in biological materials collected at the time of delivery, namely: maternal blood, amniotic fluid, umbilical cord blood, placenta, ovular remains (in initial miscarriages), swab of secretions in case of stillbirth, maternal colostrum. Virtual biopsy will also be performed in cases of stillbirth. We hope to help clarify the doubts that still linger regarding SARS-CoV-2 infection during pregnancy