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ANTIDOTE. Development of hyperimmune serum from convalescent patients and seropositive donors based on donor screening for anti-SARS-CoV-2 IgG antibody.

Grant number: unknown

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Key facts

  • Disease

    COVID-19

  • Start & end year

    N/A

  • Funder

    University of São Paulo

  • Research Location

    Brazil

  • Lead Research Institution

    Hospital das Clínicas

  • Research Priority Alignment

    N/A

  • Research Category

    Therapeutics research, development and implementation

  • Research Subcategory

    Pre-clinical studies

  • Special Interest Tags

    N/A

  • Study Type

    Clinical

  • Clinical Trial Details

    Not applicable

  • Broad Policy Alignment

    Pending

  • Age Group

    Unspecified

  • Vulnerable Population

    Unspecified

  • Occupations of Interest

    Unspecified

Abstract

Passive immunotherapy with plasma of convalescent individuals was described in the treatment of Middle East Respiratory Syndrome Coronavirus (MERS-CoV) infection in 2016 (11) and may perhaps be used in COVID-19 infection (12). In this study, we intend to screen donors weekly for anti SARS-CoV-2 and evaluate the possibility of producing hyperimmune serum from plasma routinely collected by the donor. Highly titled donors will routinely be called to donate through apheresis. The weekly data on the prevalence of seropositive donors will also be used to infer the evolution of the epidemic in our city and in mathematical models that they can.